The NIPT examination (non-invasive prenatal test) is a test performed on a pregnant woman’s blood sample, which can be used to screen for the risk of certain fetal chromosomal disorders. Although it is possible to take the NIPT test after 10 weeks of pregnancy, the best time to take the sample is after 11+0 weeks of pregnancy, when there is more fetal cell-free DNA in the mother’s bloodstream. During pregnancy, cell-free DNA is released from the fetus’s bloodstream into the mother’s bloodstream, which can be isolated from a blood sample taken from the mother. From this cell-free DNA, the number of chromosomes of the fetus can be determined, among other things, without the risk of miscarriage. Since the NIPT test is based on probabilities, an abnormal finding must be confirmed by amniocentesis or a placental sample. If the NIPT is abnormal, about 0.1 percent of the abnormal findings turn out to be normal by amniocentesis or placental sampling.
In order to take the NIPT test, a sampling appointment must be booked. At the same visit, an ultrasound examination during pregnancy is also performed, where the duration of the pregnancy and the normal growth and development of the fetus are ensured, and advice is given for the NIPT test. The results of the NIPT test come within 1 weeks of taking the sample. If the result of the NIPT examination is abnormal, the significance of the findings will be reviewed and at the same time the possibility of a referral for further examinations will be offered.
The basic NIPT test is available at all our clinics and the extensive NIPT examination of all chromosomes (NACE24) at the Tampere, Kuopio and Helsinki clinics.
Make an appointment for the NIPT examination:
Appointments and inquiries from Monay to Friday 8.15–15.00 tel. +358 20 747 9310.
Appointments and inquiries Mon-Fri 8.15–15.00 tel. +358 20 747 9314.
Appointments and inquiries mon-fri 8-16.00 Tel. 017 263 1700
Basic NIPT determines the risk of Down syndrome (trisomy 21), Patau syndrome (trisomy 13) and Edwards syndrome (trisomy 18). The sex of the fetus can also be determined from the sample, which makes it possible to exclude Turner syndrome (XO) and Klinefelter syndrome (XXY). In connection with the answers, the sex of the fetus is indicated, if this is wanted to know. The sample is taken from a pregnant woman as a blood sample, in which case there is no risk of miscarriage.
The NIPT test used in Ovumia detects more than 99.9 percent of trisomy 21 pregnancies and 99.9 percent of trisomy 13 and 18 pregnancies. NIPT correctly identifies the gender with more than 99 percent probability. The reliability of the NIPT test for disorders of the sex chromosomes is over 91 percent.
A basic NIPT examination is possible in multiple pregnancies, but in this case analysis of the sex chromosomes cannot be done. In multiple pregnancies, the sex can only be reliably determined if both fetuses are girls. In multiple pregnancies, abnormal numbers of sex chromosomes cannot be examined with a basic NIPT examination.
Since the basic NIPT works as part of the risk assessment during pregnancy, taking the test always requires counseling and an ultrasound scan at the doctor’s office.
Book an appointment for a basic NIPT examination in Jyväskylä, Kuopio, Tampere or Helsinki:
NIPT of all chromosomes (NACE24) covers all chromosomes (1-22 and sex chromosomes) in addition to large (more than 7mb in size) partial deletions and duplications (microdeletions and duplications) of chromosomes. The sample is taken from a pregnant woman as a blood sample, in which case there is no risk of miscarriage. The NIPT test for all chromosomes can be taken from the 10th week of pregnancy.
All-chromosome NIPT detects chromosome number 21, 13, and 18 abnormalities at least 99.9 percent of the time. Abnormalities in the number of sex chromosomes are found in at least 91 percent. The NIPT of all chromosomes identifies the sex of the fetus with more than 99 percent accuracy.
In addition, the risk of a false positive result in the NIPT study of all chromosomes is 0.1 percent. Regarding abnormalities in the number of chromosomes other than 21, 13 and 18, the study finds at least 96 percent of the abnormalities, internal partial absences or duplications of chromosomes are found in at least 74 percent.
The NIPT test for all chromosomes is only possible in singleton pregnancies.
The NIPT test for all chromosomes functions as part of the risk assessment during pregnancy, and for this reason, taking the test always requires counseling and an ultrasound examination at the doctor’s office.
Reserve time for the NACE24 examination at the Tampere and Helsinki clinics:
Appointments and inquiries from Monay to Friday 8.15–15.00 tel. +358 20 747 9310.
Appointments and inquiries Mon-Fri 8.15–15.00 tel. +358 20 747 9314.
The POC test (products of conception) provides information about fetal causes of miscarriages. In the POC study, disorders based on the number of chromosomes are investigated for all 46 chromosomes (23 chromosome pairs). The results are obtained in more than 99 percent of the samples if enough pregnancy material has been obtained. The sample is taken from the discharge of the miscarriage or at the reception under local anesthesia with suction drainage of the uterus (MVA). An abnormal result is opened at the reception, and possible follow-up examinations are planned for the customer and his spouse. Abnormal results of the Ovumia POC test can also be used in preimplantation diagnostics (PGT) of infertility treatments.
Asking more about the POC test Ovumia from Tampere.
Appointments and inquiries from Monay to Friday 8.15–15.00 tel. +358 20 747 9310.
